Cytochrome bd Oxidase and Hydrogen Peroxide Resistance in Mycobacterium tuberculosis
نویسندگان
چکیده
Department of Biochemical Sciences and Istituto Pasteur, Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italya; Belozersky Institute of PhysicoChemical Biology, Lomonosov Moscow State University, Leninskie Gory, Moscow, Russian Federationb; Institute for Oriental and Classical Studies, Russian State University for the Humanities, Moscow, Russian Federationc; CNR Institute of Molecular Biology and Pathology, Rome, Italyd
منابع مشابه
The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress
Targeting respiration and ATP synthesis has received strong interest as a new strategy for combatting drug-resistant Mycobacterium tuberculosis. Mycobacteria employ a respiratory chain terminating with two branches. One of the branches includes a cytochrome bc1 complex and an aa3-type cytochrome c oxidase while the other branch terminates with a cytochrome bd-type quinol oxidase. In this commun...
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Targeting oxidative phosphorylation recently has received strong interest as new strategy for combating drug-resistant Mycobacterium tuberculosis. Several components of oxidative phosphorylation such as the type-II NADH dehydrogenase, the cytochrome bc1 complex and ATP synthase have been exploited as target and drugs inhibiting these complexes presently are in clinical development. However, the...
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UNLABELLED Mycobacterium tuberculosis depends on aerobic respiration for growth and utilizes an aa3-type cytochrome c oxidase for terminal electron transfer. Cytochrome c maturation in bacteria requires covalent attachment of heme to apocytochrome c, which occurs outside the cytoplasmic membrane. We demonstrate that in M. tuberculosis the thioredoxin-like protein Rv3673c, which we named CcsX, i...
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Cytochrome bd is a prokaryotic terminal oxidase that catalyses the electrogenic reduction of oxygen to water using ubiquinol as electron donor. Cytochrome bd is a tri-haem integral membrane enzyme carrying a low-spin haem b558, and two high-spin haems: b595 and d. Here we show that besides its oxidase activity, cytochrome bd from Escherichia coli is a genuine quinol peroxidase (QPO) that reduce...
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